
Nicolas Buchler – NC State College of Veterinary Medicine
- Deep learning-driven imaging of cell division and cell growth across an entire eukaryotic life cycle, MOLECULAR BIOLOGY OF THE CELL (2025)
- Diploid-dominant life cycles characterize the early evolution of Fungi, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)
- Competition for DNA binding between paralogous transcription factors determines their genomic occupancy and regulatory functions, GENOME RESEARCH (2021)
Nicolas Buchler
Associate Professor of Molecular Biomedical Sciences
CIFR Executive Committee
About Dr. Nicolas Buchler
Dr. Nicolas Buchler joined NC State University in July 2018 as part of the Chancellor’s Faculty Excellence Program in Modeling the Living Embryo. His research focuses on understanding how the cell cycle interacts with metabolic rhythms, and how disruptions in these processes contribute to disease or lead to new biological functions. The lab primarily works with early-diverging fungi and yeasts, but they also collaborate with others to explore similar questions in various regulatory systems (e.g., circadian clocks) and organisms (e.g., animals and plants).
Dr. Buchler earned a B.S. in Physics from the University of California, San Diego before pursuing a Ph.D. in Biophysics at the University of Michigan, where he focused on protein structure and evolution. His postdoctoral work, first at UC San Diego and later at the Center for Studies in Physics & Biology at Rockefeller University, combined mathematical modeling with experimental work to understand how gene networks sense and respond to signals, store memories of past events, and schedule periodic processes like the cell cycle.
Education
- Ph.D. in Biophysics, University of Michigan, 2001
Areas of Expertise
- Biological Oscillations (e.g., cell cycle, metabolic rhythms)
- Fungal Genomics & Evolution
- Single-Cell Gene Expression
- Mathematical Modeling of Gene Regulatory Dynamics
Groups
- Research Area of Emphasis: Computational Biology and Bioinformatics
- CVM
- Developmental Biology
- Research Area of Emphasis: Genetics
- Molecular Biomedical Sciences: MBS Faculty
- Molecular Biomedical Sciences: MBS Researchers
- CVM: Molecular Biomedical Sciences
- CVM: Research Area of Emphasis
Honors and Awards
- NIH Director’s New Innovator Award, National Institutes of Health, 2011
- Career Award at the Scientific Interface, Burroughs Wellcome Funds, 2006